(a) (b)

a) The DSG model structure constructed for a simulated data set. (b) The ROC

he DSG model structure constructed for a simulated data set. The AUC was

The varying performance (AUC) of the DSG models constructed based on the

he varying overlap degrees between the null density of non-DEGs and the

density of DEGs.

ext simulated data was designed in a two-dimensional space [Al

2015]. It was also composed of 900 non-DEGs, 50 down-

DEGs and 50 up-regulated DEGs. To assess the performance of

ee other algorithms which can only detect DEGs for replicated

e used. They are the eBayes, the SAMr [Tusher, et al., 2001] and

rT [Baldi and Long, 2001; Kayala, and Baldi, 2012]. Figure

hows the ROC curves and the AUC values of four models. Their

nce was similar although DSG outperformed the others slightly.

51(b) shows the Venn diagram between four models for the two-

nal simulated data. This consensus analysis also shows that four

emonstrated a high degree of agreement in DEG detection.